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Probing the Signal Transduction Mechanism of the Light-Activated Adenylate Cyclase OaPAC Using Unnatural Amino Acid Mutagenesis

https://doi.org/10.1021/acschembio.4c00627

Jewlikar, Samruddhi S; Tolentino_Collado, Jinnette; Ali, Madeeha I; Sabbah, Aya; He, YongLe; Iuliano, James N; Hall, Christopher R; Adamczyk, Katrin; Greetham, Gregory M; Lukacs, Andras; et al (February 2025, ACS Chemical Biology)

Free, publicly-accessible full text available February 21, 2026
Site-Specific Protein Dynamics Probed by Ultrafast Infrared Spectroscopy of a Noncanonical Amino Acid

https://doi.org/10.1021/acs.jpcb.9b09425

Hall, Christopher R.; Tolentino Collado, Jinnette; Iuliano, James N.; Gil, Agnieszka A.; Adamczyk, Katrin; Lukacs, Andras; Greetham, Gregory M.; Sazanovich, Igor; Tonge, Peter J.; Meech, Stephen R. (October 2019, The Journal of Physical Chemistry B)

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Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix

https://doi.org/10.1021/acschembio.0c00543

Iuliano, James N.; Tolentino Collado, Jinnette; Gil, Agnieszka A.; Ravindran, Pavithran T; Lukacs, Andras; Shin, SeungYoun; Woroniecka, Helena A; Adamczyk, Katrin; Aramini, James M.; Edupuganti, Uthama R; et al (September 2020, ACS Chemical Biology)

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Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis

https://doi.org/10.1021/acschembio.2c00575

Tolentino Collado, Jinnette; Iuliano, James N.; Pirisi, Katalin; Jewlikar, Samruddhi; Adamczyk, Katrin; Greetham, Gregory M.; Towrie, Michael; Tame, Jeremy R. H.; Meech, Stephen R.; Tonge, Peter J.; et al (August 2022, ACS Chemical Biology)

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